Novel organic-inorganic materials in opto-electronic systems for the monitoring and control of bio-processes

MatinoesBiotechnological processes can be found in food, drink and pharmaceutical industries, waste processing or environmental protection and they need affordable and rapid sensing techniques. MATINOES was aimed in the development of novel enzyme based fiber optic sensors for applications in biotechnological production processes to cover the lack of sensors suitable for in-site, continuous monitoring of reactants under harsh reaction conditions.

Duration: November 2002 - October 2005

The partnership had 9 partners from 5 different countries. It contains internationally recognized specialists in: inorganic-organic coating materials, enzyme preparation, enzymatic reactions, design and preparation of optical fibers, and sensor design. The project also involved SMEs involved in the design and supply of biochemical plants and instrumentation, and the manufacture of fiber-optic instrumentation.


Optical sensor system for fluorescence lifetime measurement was developed in the project. Sensor uses high sensitive photo multiplier tube (PMT) as detector of fluorescence signal. System is able to use intrinsic and extrinsic sensor probe too. High-speed synchronous principle of detection is able to eliminate optical interference (ambient light). There are measured fluorescence intensities in several times during fluorescence decaying. The unique data processing method was developed to obtain low noise results. 
Measurement parameters were optimised in order to get good system response, sensitivity and resolution. It was confirmed that this process was very important to get real fluorescence lifetime changes measurement. Two systems were developed in the project one channel and multi-channel. One channel system was adapted for industrial use. Extrinsic sensor probe using plastic optical fibres was used. Silica or PMMA lens with prepared sensing layer (ORMOCER) were placed in removable probe cap. Sensor was installed at industrial partner Moorepark during project. The second one multi-channel system is able to detect a few different analytes. This system is tested in laboratory bioreactor (installed at ICPF). It is possible to effective evaluating of new prepared ORMOCER layers. 

There are a few responses from industry and research institutions from Czech Republic. 
These institutions are interested in testing the system in their processes.



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